In vitro-in vivo correlation study on nimesulide loaded hydroxypropylmethylcellulose microparticles.
- Author:
Shujaat Ali KHAN
1
;
Mahmood AHMAD
;
Ghulam MURTAZA
;
Muhammad Naeem AAMIR
;
Rozina KOUSAR
;
Fatima RASOOL
;
Shahiq-u-Zaman
Author Information
1. Faculty of Pharmacy & Alternative Medicine, Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
- Publication Type:Journal Article
- MeSH:
Anti-Inflammatory Agents, Non-Steroidal;
administration & dosage;
pharmacokinetics;
Cross-Over Studies;
Cyclooxygenase 2 Inhibitors;
administration & dosage;
pharmacokinetics;
Delayed-Action Preparations;
Humans;
Hypromellose Derivatives;
Methylcellulose;
analogs & derivatives;
Microspheres;
Models, Chemical;
Sulfonamides;
administration & dosage;
pharmacokinetics
- From:
Acta Pharmaceutica Sinica
2010;45(6):772-777
- CountryChina
- Language:English
-
Abstract:
This study involves mathematical simulation model such as in vitro-in vivo correlation (IVIVC) development for various extended release formulations of nimesulide loaded hydroxypropylmethylcellulose (HPMC) microparticles (M1, M2 and M3 containing 1, 2, and 3 g HPMC, respectively and 1 g drug in each) having variable release characteristics. In vitro dissolution data of these formulations were correlated to their relevant in vivo absorption profiles followed by predictability worth analysis of these Level A IVIVC. Nimaran was used as control formulation to validate developed formulations and their respective models. The regression coefficients of IVIVC plots for M1, M2, M3 and Nimaran were 0.834 9, 0.831 2, 0.927 2 and 0.898 1, respectively. The internal prediction error for all formulations was within limits, i.e., < 10%. A good IVIVC was found for controlled release nimesulide loaded HPMC floating M3 microparticles. In other words, this mathematical simulation model is best fit for biowaiver studies which involves study parameters as those adopted for M3 because the value of its IVIVC regression coefficient is the closest to 1 as compared to M1 and M2.
