Effect of ZL-004 on raising leukocyte count.
- Author:
Hai-Yan SUN
1
;
Chun-Gang LI
;
Lin XIAO
;
Guo-Ping WANG
;
Quan-Hai LIU
Author Information
1. Shanghai Institute of Pharmaceutical Industry, Shanghai 200437, China. sunny701219@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Animals;
Antineoplastic Agents;
pharmacology;
Bone Marrow Cells;
cytology;
Cell Differentiation;
drug effects;
Cell Proliferation;
drug effects;
Female;
Fluorouracil;
Granulocytes;
cytology;
drug effects;
Leukocyte Count;
Leukocytes;
cytology;
drug effects;
Leukopenia;
chemically induced;
pathology;
Male;
Mice;
Mice, Inbred BALB C;
Molecular Structure;
Pyrrolidinones;
chemistry;
pharmacology;
Random Allocation
- From:
Acta Pharmaceutica Sinica
2010;45(6):797-800
- CountryChina
- Language:Chinese
-
Abstract:
This study is to investigate the effect of ZL-004 on normal mouse and mice with leukopenia induced by chemotherapeutic agents. 5-Fluorouracil were administered intraperitoneally to mice to develop leucopenia, and the mice were treated with ZL-004. The number of peripheral leukocytes and the percentage of granulocyte in total WBC were examined. The results are that ZL-004 markedly raise peripheral blood leukocytes in the normal mice and the mice model of leukopenia. So, ZL-004 could protect mice against 5-fluorouracil damage and raise peripheral blood leukocyte. Features of bone marrow smears is myeloproliferative hyperactivity in the mice, particularly the matured granulocytic series were observed. The mechanism of ZL-004 is to act on the mouse bone marrow causing proliferation and differentiation.
