Synthesis of calophyllolide analogue and its preliminary anti-inflammatory activity.
- Author:
Tao MA
1
;
Lin WANG
;
Gui-fang CHENG
;
Gang LIU
Author Information
1. Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Anti-Inflammatory Agents, Non-Steroidal;
chemical synthesis;
chemistry;
therapeutic use;
Carrageenan;
Coumarins;
chemical synthesis;
chemistry;
pharmacology;
therapeutic use;
Edema;
chemically induced;
drug therapy;
Male;
Molecular Structure;
Rats;
Rats, Wistar
- From:
Acta Pharmaceutica Sinica
2010;45(10):1265-1269
- CountryChina
- Language:English
-
Abstract:
A new pyranocoumarin as an analogue of calophyllolide, compound 6, is firstly prepared and reported to have potent anti-inflammatory activity on carrageenin-induced edema in rats.