A new cytotoxic metabolite from a deep sea derived fungus, Phialocephala sp.
- Author:
Li CHEN
1
;
De-hai LI
;
Sheng-xin CAI
;
Feng-ping WANG
;
Xiang XIAO
;
Qian-qun GU
Author Information
1. Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou 350002, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Antineoplastic Agents;
chemistry;
isolation & purification;
pharmacology;
Ascomycota;
chemistry;
Cell Line, Tumor;
Cell Survival;
drug effects;
Humans;
Hydroquinones;
chemistry;
isolation & purification;
pharmacology;
Inhibitory Concentration 50;
K562 Cells;
Leukemia P388;
pathology;
Mice;
Molecular Structure
- From:
Acta Pharmaceutica Sinica
2010;45(10):1275-1278
- CountryChina
- Language:English
-
Abstract:
A new sesquiterpene hydroquinone (1) was isolated from a deep sea sediment derived fungus, Phialocephala sp.. Its structure and stereochemistry were established on the basis of spectroscopic data and optical rotation. This compound was tested for cytotoxicity against P388 (murine leukemia cell) and K562 (human leukemia cell) cell lines, and displayed strong cytotoxic effects with IC50 value of 0.16 and 0.05 micromol x L(-1), separately.
