Advances in the targeting ATP-binding cassette transporters to overcome tumor multi-drug resistance.
- Author:
Ning WEI
1
;
Hua SUN
;
Geng-tau LIU
Author Information
1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. weining@imm.ac.cn
- Publication Type:Journal Article
- MeSH:
ATP-Binding Cassette Transporters;
antagonists & inhibitors;
chemistry;
metabolism;
physiology;
Antineoplastic Agents;
therapeutic use;
Drug Resistance, Multiple;
Drug Resistance, Neoplasm;
Humans;
Neoplasms;
drug therapy;
physiopathology
- From:
Acta Pharmaceutica Sinica
2010;45(10):1205-1211
- CountryChina
- Language:Chinese
-
Abstract:
ATP-binding cassette (ABC) transporters are a family of proteins that mediate multi-drug resistance (MDR) via ATP-dependent drug efflux pumps. Abnormally expression and function would result in tumor MDR. That is the most important mechanism of MDR. The inhibition of ABC transporters as a strategy to reverse MDR in cancer has been studied extensively. In this review, we reviewed the structure and function of ABC transporters, and focused on the research advances in the mechanism of tumors MDR mediated by ABC transporters and the development of their modulators and reversal strategies.
