The role of matrix metalloproteinases and their tissue inhibitors in oral lichen planus.
- Author:
Wei-ping ZHANG
1
;
Yu CHEN
;
Ning GENG
;
Kun TIAN
;
Dong-mei BAO
;
Ming-zhong YANG
Author Information
- Publication Type:Journal Article
- MeSH: Carcinoma, Squamous Cell; metabolism; pathology; Humans; Immunohistochemistry; Lichen Planus, Oral; metabolism; pathology; Matrix Metalloproteinase 14; metabolism; Matrix Metalloproteinase 2; metabolism; Mouth Mucosa; metabolism; pathology; Mouth Neoplasms; metabolism; pathology; Tissue Inhibitor of Metalloproteinase-2; metabolism
- From: Chinese Journal of Stomatology 2006;41(7):420-421
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the role of MMP-2, MT1-MMP and TIMP-2 in the carcinogenesis of oral lichen planus (OLP).
METHODSImmunohistochemistry was performed to examine the expression of OLP and compare with that of NOM.
RESULTSThe expression of these proteinases significantly increased from NOM, non-atrophic OLP, to atrophic OLP and OSCC. The expression of MMP-2 and MT1-MMP in atrophic OLP was significantly higher than in non-atrophic OLP. Furthermore, the expression of TIMP-2 consequently increased with the increasing of the MMP, but the increase of TIMP-2 was less than that of MMP.
CONCLUSIONSMMP may be useful marker to judge the possibility of malignant change of OLP.
