Coexpression of Schwann cell marker GFAP and myoepithelial cell marker alpha-SMA in salivary adenoid cystic carcinoma.

Author: Mo-yi SUN ¹ ; Wei CHEN ; Lian-jia YANG ; Shao-zhong DONG
Author Information

1. Department of Oral and Maxillofacial Surgery, College of Stomatology, The Fourth Military Medical University, Xi'an 710032, China. moyisun@fmmu.edu.cn
Publication Type:Journal Article
MeSH: Actins; metabolism; Carcinoma, Adenoid Cystic; metabolism; pathology; Epithelial Cells; metabolism; pathology; Glial Fibrillary Acidic Protein; metabolism; Humans; Muscle Cells; metabolism; pathology; Salivary Gland Neoplasms; metabolism; pathology; Schwann Cells; metabolism; pathology
From: Chinese Journal of Stomatology 2006;41(8):461-463
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo observe the expression of Schwann cell marker GFAP and myoepithelial cell marker alpha-SMA in salivary adenoid cystic carcinoma (ACC), and to evaluate the relationship of GFAP, alpha-SMA and perineural invasion in ACC.
METHODSImmunohistochemical SABC method, double-label immunofluorescence and CLSM were used to detect the expression of GFAP and alpha-SMA proteins in salivary ACC tissue samples.
RESULTSIn salivary ACC tissue samples, both GFAP and alpha-SMA proteins were positive, which were coexpressed in cytoplasm of the same onco-myoepithelial cells.
CONCLUSIONSThere may be Schwann cell differentiation in onco-myoepithelial cell of salivary ACC, and it may be the pathological base of perineural invasion in salivary ACC.