The expression of the immediate early genes, c-fos, krox-24 and the late response gene, BKNF induced by antiepileptic drugs.
- Author:
Soon Chun SUH
1
;
Young Choon PARK
;
Soo Kyung KIM
Author Information
1. Department of Neurology, College of Medicine, Keimyng University.
- Publication Type:Original Article
- MeSH:
Animals;
Anticonvulsants*;
Brain-Derived Neurotrophic Factor;
Convulsants;
Diazepam;
Dizocilpine Maleate;
Genes, Immediate-Early*;
Glioma;
Glutamic Acid;
Kainic Acid;
N-Methylaspartate;
Phenytoin;
Picrotoxin;
Rats
- From:Journal of the Korean Neurological Association
1997;15(3):542-554
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The expression of the c-fos and krox-24 (immediate early genes: IEGs) and the BDNF (late response gene) were investigated by convulsants such as kainate (KA, 200 micrometer), N-methyl-D-aspartate (NMDA, 10 mM), glutamate (GLU, 2 mM), and picrotoxin (PTX, 20 micrometer in the rat C6 glioma cells. In addition, the changes of their expression patterns were investigated by the anticonvulsants such as a NMDA antagonist MK-801, phenytoin, phenobarbiw, diazepam, and newer antiepileptic drugs like felbamate and gabapentin. NMDA induced c-fos and krox-24 expromiom were decreased spatially by the anticonvulsants. KA, NMDA, GLU, and PTX-induced BDNF expression were increased by the anticonvulsants. These results imply the molecular basis of the anticonvulsant action mechanism lies in differential and coordinated transcriptional regulation of IEGs.
