The mechanotransduction mechanism of how osteoblasts respond to mechanical stimulation.
- Author:
Yuanliang WANG
1
;
Liling TANG
;
Jianhua WANG
;
Shaoxi CAI
Author Information
1. Key Lab. of Biomechanics & Tissue Engineering under the State Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China. wyl@cqu.edu.cn
- Publication Type:Journal Article
- MeSH:
Biomechanical Phenomena;
Calcium;
physiology;
Humans;
Mechanotransduction, Cellular;
Osteoblasts;
physiology;
Osteocalcin;
biosynthesis;
Proto-Oncogene Proteins c-fos;
biosynthesis;
genetics;
Proto-Oncogene Proteins c-jun;
biosynthesis;
genetics;
Signal Transduction;
Stress, Mechanical
- From:
Journal of Biomedical Engineering
2005;22(2):400-402
- CountryChina
- Language:Chinese
-
Abstract:
The stress environment regulates the factors of growth, resorption and remolding in bone tissue. Mechanical stimulation at cell physical level affects the physiological activity of osteoblasts, including proliferation, ALP activity and osteocalcin production. Mechanotransduction is a procedure which transduces the biophysical force into biochemical responses. It is also the basis of many physiological functions. The early response genes (c-fos, c-jun), the second message systems (Ca2+, NO, cAMP) and the mechano-sensitive cation channel are involved in the mechanotransduction course when osteoblasts respond to the mechanical stimulation.
