Culture of chondrocytes onto poly-DL-lactide scaffoldings: experimental study.
- Author:
Zhi PENG
1
;
Yueming SONG
;
Dingguo WANG
;
Limin LIU
;
Yongli DING
Author Information
1. Department of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- MeSH:
Cells, Cultured;
Chondrocytes;
cytology;
Polyesters;
chemistry;
Porosity;
Tissue Engineering;
Tissue Scaffolds;
chemistry
- From:
Journal of Biomedical Engineering
2005;22(3):518-520
- CountryChina
- Language:Chinese
-
Abstract:
This experimental study was intended to find the possibility of using PDLLA as scaffolds in tissue engineering and to assess the effect of PDLLA scaffolds with different porosity on chondrocytes. Chondrocytes were cultured when they were seeded onto PDLLA scaffolds with different porosity. Under scanning electron microscope, the scaffolds in hydrophila and adsorptivity to chondrocytes and the function of the cells were observed. The chondrocytes were noted to proliferate on PDLLA scaffolds with different porosity, those with 90%-96% porosity being significantly better. So PDLLA can be used as a scaffold in tissue engineering, and the proper porosity of PDLLA scaffolds should be 90% approximately 96%.
