Structure charateristics of mitoxantrone transforsomes.
- Author:
Tong CHEN
1
;
Shixiang HOU
;
Biqiong SHI
;
Yu ZHENG
;
Yiyi SUN
;
Yunfei TIAN
Author Information
1. Department of Pharmaceutics Sciences, School of Pharmacy, Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- MeSH:
Anthraquinones;
chemistry;
Calorimetry, Differential Scanning;
Delayed-Action Preparations;
chemistry;
Lecithins;
chemistry;
Mitoxantrone;
chemistry;
Spectrophotometry
- From:
Journal of Biomedical Engineering
2005;22(3):555-559
- CountryChina
- Language:Chinese
-
Abstract:
This study sought to clarify the molecular location and the interaction between mitoxantrone and mitoxantrone transforsomes. The anthraquinone of mitoxantrone, a heterocyclic ring that intercalates in the lipid of bilayer, was determined by UV-spectrophotometry and electron probes scan microscopy. Two aminoethylamino side-chains of the drugs fit to the phosphates of lecithin were determined by 8-value, thus the interaction with lecithin was substantiated. Differential scanning calorimetry confirmed that mitoxantrone has remarkable stabilizing effect on the mitoxantrone transforsomes membrane. The mitoxantrone binds tightly to lecithin. So a high degree of encapsulation efficiency and the sustained-release character of mitoxantrone transforsomes are verified.
