Summarization in the research of canstatin.
- Author:
Yuying LI
1
;
Guisheng QIAN
;
Guijun HUANG
Author Information
1. Institute of Respiratory Disease, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China. lzhlyyhy@163.com
- Publication Type:Journal Article
- MeSH:
Angiogenesis Inhibitors;
pharmacology;
Animals;
Antineoplastic Agents;
pharmacology;
Collagen Type IV;
pharmacology;
Humans;
Mice
- From:
Journal of Biomedical Engineering
2005;22(3):626-628
- CountryChina
- Language:Chinese
-
Abstract:
Canstatin protein, a newly found angiogenesis inhibitor, has powerful anti-angiogenesis effect. Canstatin is the N terminal fragment of collagen IV alpha2 chain NC1 domain. Its distinct anti-cancer effect in mouse model and low toxicity has not only made it a promising new anti-cancer drug candidate, but also drawn much attention of researchers. The detection, denomination, biological characters and mechanism of canstatin protein, and also the prospect of its application were summarized.
