Research on endothelialization of artificial vascular grafts.
- Author:
Suhua QIN
1
;
Jun PAN
;
Keda WU
Author Information
1. Key Laboratory of Biomechanics and Tissue Engineering, State Ministry Education, College of Biology Engineering, Chongqing University, Chongqing 400044, China.
- Publication Type:Journal Article
- MeSH:
Blood Vessel Prosthesis;
Endothelial Cells;
cytology;
Endothelium, Vascular;
growth & development;
Genetic Therapy;
Humans;
Stress, Mechanical
- From:
Journal of Biomedical Engineering
2005;22(3):629-632
- CountryChina
- Language:Chinese
-
Abstract:
Endothelialization of artificial vascular graft is considered as one of the most promising methods to improve its antithrombotic ability and long-term patency. Endothelialization of artificial vascular graft includes harvesting endothelial cells, choosing some materials with better compliance and seeding endothelial cells. The methods such as immobilization of extracellular matrix protein and growth factor to substrates, stimulation of chronic in vitro shear stress for endothelial cell retention on artificial vascular graft in bioactor, genetic modificatioin of ECs, and changes of electric charge of ECs are used to increase the adherence ability of endothelial cells. This paper reviews the process of endothelialization of artificial vascular graft and makes brief comments on the methods of endothelialization of artificial vascular graft.
