Influence of iridoid from Valeriana jatamansi on 5-HT and 5-HIAA in rats with irritable bowel syndrome.
- Author:
Xingli YAN
1
;
Ying HONG
;
Jinli SHI
;
Yi QIN
;
Jianjun ZHANG
;
Qing LIN
;
Zhenzhen CHEN
;
Ren ZHAO
;
Xiaoli CUI
;
Xuemin GAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Chromatography, High Pressure Liquid; Colon; drug effects; metabolism; Hydroxyindoleacetic Acid; blood; metabolism; Hypothalamus; drug effects; metabolism; Iridoids; therapeutic use; Irritable Bowel Syndrome; blood; drug therapy; metabolism; Male; Rats; Rats, Sprague-Dawley; Serotonin; blood; metabolism; Valerian; chemistry
- From: China Journal of Chinese Materia Medica 2011;36(9):1235-1238
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the mechanism of iridoid from Valeriana jatamansi treating irritable bowel syndrome.
METHODSixty male SD rats were equally divided into 6 groups (2 controls, 1 model and 3 treatment doses) with 10 rats per group. The test groups were administered with iridoid (24.92, 12.46, 6. 23 mg x kg(-1)) while the control groups were administered with fluoxetine (2.5 mg x kg(-1), positive control) or distilled water (negative control). The model was established by chronic stress and independent feeding. The influence of iridoid from V. jatamansi on 5-HT and 5-HIAA in colon, serum and hypothalamic were observed in all groups.
RESULTIn the model group, the content of 5-HT in colon and serum increased significantly, but the content of 5-HT in hypothalamic decreased significantly. The content of 5-HIAA and the value of 5-HT/5-HIAA had no significant change. In three iridoid-treated groups, the content of 5-HT in colon and serum decreased, but the content of 5-HT in hypothalamic increased. The content of 5-HIAA had no significant change. The value of 5-HT/5-HIAA in colon and serum reduced.
CONCLUSIONThe mechanism of iridoid from V. jatamansi treating irritable bowel syndrome may be related to the regulation effect to the levels of 5-HT from Gastrointestinal to central nervous system.
