Therapeutic effects of saponins from Achyranthes bidentata in SHRsp.
- Author:
Lijun WANG
1
;
Yan ZHU
;
Maochuan LIAO
Author Information
- Publication Type:Journal Article
- MeSH: Achyranthes; chemistry; Animals; Antihypertensive Agents; therapeutic use; Hypertension; drug therapy; Male; Random Allocation; Rats; Rats, Inbred SHR; Saponins; therapeutic use
- From: China Journal of Chinese Materia Medica 2011;36(9):1239-1241
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the therapeutic effects of saponins from Achyranthes bidentata (SAB) in stroke-prone sponyaneously hypertension rats (SHRsp).
METHODSixty SHRsp were randomly divided into five groups: SAB 0.10, 0.20, 0.40 g x kg(-1), Huatuo Zaizao pill group (positive control group) 2.5 g x kg(-1) and pathologic group (n=10). SAB and Huatuo Zaizao pill were used through filing stomach everyday for 20 days, pathologic group was given distilled water. The effects of SAB on blood pressure, changes of nerve state, death rate, brain index and the pathologic changes of hippocampal neuron of SHRsp were observed.
RESULTSAB could markedly decrease brain index, death rate of SHRsp after stroke. SAB could improve nerve state of SHRsp after stroke. Also SAB could prolong survival time and prevent pathologic change of hippocampal neuron of SHRsp after stroke.
CONCLUSIONSAB is advantageous of therapying the stroke in SHRsp.
