Chemical constitutents from pre-formulation of lonicerae japonicae flos in shuanghuanglian lyophilized powder for injection.
- Author:
Nan WANG
1
;
Xiuwei YANG
Author Information
- Publication Type:Journal Article
- MeSH: Chlorogenic Acid; chemistry; Drugs, Chinese Herbal; chemistry; Flowers; chemistry; Freeze Drying; Lonicera; chemistry; Oleanolic Acid; analogs & derivatives; chemistry; Quinic Acid; analogs & derivatives; chemistry; Rutin; chemistry; Saponins; chemistry
- From: China Journal of Chinese Materia Medica 2011;36(12):1613-1619
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo research the chemical constitutents for the pre-formulation of Lonicerae Japonicae Flos (the dried buds of Lonicera japonica) in Shuanghuanglian lyophilized powder for injection and provide substance foundation for the adverse reaction of Shuanghuanglian lyophilized powder for injection.
METHODThe chemical constituents were isolated by column chromatography and preparative HPLC. All structures were characterized by the spectroscopic methods including ESI-MS, 1H-NMR, 13C-NMR, and compared with data in the literature.
RESULTTwenty compounds were isolated and identified as sophoraricoside(1), luteolin-7-O-beta-D-glucopyranoside(2), rutin(3), quercetin(4), 3,5-O-dicaffeoyl quinic acid methyl ester(5), 4,5-O-dicaffeoyl quinic acid methyl ester(6), 3,4-O-dicaffeoyl quinic acid methyl ester(7), 4,5-dicaffeoyl quinic acid(8), 3,4-dicaffeoyl quinic acid(9), chlorogenic acid(10), epi-vogeloside (11), sweroside(12), vogeloside(13), secoxyloganin(14), macranthoidin A(15), macranthoidin B(16), loniceroside A(17), loniceroside B(18), loniceroside C(19), dipsacoside B(20).
CONCLUSIONCompound 1 was identified in genus Lonicera for the first time and compounds 1-20 were isolated from the pre-formulation for the first time.
