Protective effect of hydroxysafflor yellow A on endothelial cell injury induced by lipopolysaccharide.
- Author:
Xiaofei WANG
1
;
Baoxia ZANG
;
Wei WU
;
Jing TONG
;
Ming JIN
Author Information
1. Department of Pharmacology, Beijing Institute of Heart Lung and Blood Vessel Diseases-Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China. wangxiaofei610@sina.com
- Publication Type:Journal Article
- MeSH:
Cell Line;
Chalcone;
analogs & derivatives;
pharmacology;
Endothelial Cells;
drug effects;
metabolism;
Humans;
Intercellular Adhesion Molecule-1;
metabolism;
Interleukin-6;
metabolism;
Lipopolysaccharides;
toxicity;
NF-kappa B;
metabolism;
Quinones;
pharmacology;
Reverse Transcriptase Polymerase Chain Reaction;
Tumor Necrosis Factor-alpha;
metabolism;
Vascular Cell Adhesion Molecule-1;
metabolism
- From:
China Journal of Chinese Materia Medica
2011;36(12):1650-1653
- CountryChina
- Language:Chinese
-
Abstract:
To observe the protective effect of hydroxyl safflor yellow A (HSYA) on endothelial cell (EC). It has been observed by RT-PCR that HSYA can inhibit the elevation of TNF-alpha, IL-6, ICAM-1 and VCAM-1 mRNA level induced by LPS. The result of immunofluorescence test suggested that HSYA can alleviate p65 subgroup of NF-kappaB nuclear translocation. The experiment on EA-HY926 cell line proved that HSYA can protect EC against inflammation injury.
