Experimental model of histamine-induced anaphylactoid reaction on beagle dogs.
- Author:
Zhiguo WANG
1
;
Danqiao WANG
;
Youhua YU
;
Yikui LI
;
Yu SUI
;
Haifeng CUI
Author Information
- Publication Type:Journal Article
- MeSH: Anaphylaxis; chemically induced; Animals; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; adverse effects; Female; Histamine; administration & dosage; adverse effects; analogs & derivatives; Injections, Intravenous; Male
- From: China Journal of Chinese Materia Medica 2011;36(14):1842-1844
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo establish animal model of histamine-induced anaphylactoid reactions on Beagle dogs through intravenous injection of histamine phosphate injection.
METHODAnaphylactoid reactions was determined according to the changes of praxiology and blood pressure of Beagle dogs after one intravenous injection of histamine phosphate injection.
RESULTIt showed that typical anaphylactoid reactions be caused by histamine phosphate injection on Beagle dogs, and the response of the high-dose group was more obvious than that of the low-dose group.
CONCLUSIONIntravenous injection of histamine phosphate injection could simulate Beagle dogs to bring typical clinical anaphylactoid reaction, that could be used as a sensitive animal model to evaluate anaphylactoid reaction of traditional Chinese medicine injections (TCMIs) in the pre-clinical experiments of both TCMIs and their composition.
