Study on allergenicity of chlorogenic acid in Qingkailing injection.
- Author:
Zhiguo WANG
1
;
Danqiao WANG
;
Youhua YU
;
Yu SUI
;
Haifeng CUI
;
Meiyu ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Allergens; adverse effects; Animals; Behavior, Animal; drug effects; Chlorogenic Acid; adverse effects; Dogs; Drug Hypersensitivity; blood; Drugs, Chinese Herbal; administration & dosage; chemistry; Female; Guinea Pigs; Injections; Male
- From: China Journal of Chinese Materia Medica 2011;36(14):1870-1873
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the allergenicity of chlorogenic acid (CA) in Qingkailing injection.
METHODCA was administrated to Beagle dogs through intravenous injection, and on experimental allergic sensitization of guinea pigs, it was through intraperitoneal and intravenous injection. The behavioral changes of Beagle dogs and guinea pigs were observed, and changes of the content of histamine, IgE, IgG, IgM, ECP and IL-4 in blood were detected. Then the allergenicity of CA was determined by experimental anaphylactoid and allergic methods.
RESULTThere were no typical behavioral changes and increasement of the content of histamine, IgE, IgG, IgM, ECP and IL-4 in blood.
CONCLUSIONCA can not provoke anaphylactoid and allergic reactions.
