Study on pharmacokinetics of ferulic acid loaded liposome-in-chitosan-microspheres in rats.
- Author:
Jifen ZHANG
1
;
Huanhuan YUAN
;
Lin DU
;
Qin TNAG
;
Xiaoyu XU
Author Information
1. College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
- Publication Type:Journal Article
- MeSH:
Absorption;
Administration, Oral;
Animals;
Anticoagulants;
administration & dosage;
blood;
pharmacokinetics;
Biocompatible Materials;
Chitosan;
Coumaric Acids;
administration & dosage;
blood;
pharmacokinetics;
Delayed-Action Preparations;
Liposomes;
Male;
Microspheres;
Orbit;
blood supply;
metabolism;
Random Allocation;
Rats;
Rats, Sprague-Dawley;
Time Factors
- From:
China Journal of Chinese Materia Medica
2011;36(13):1751-1754
- CountryChina
- Language:Chinese
-
Abstract:
In this paper, the pharmacokinetics of ferulic acid loaded liposome-in-chitosan-microspheres was investigated. Eighteen Sprague-Dawley rats were divided into 3 groups randomly. Each group was administered orally of ferulic acid, ferulic acid loaded chitosan microspheres and ferulic acid loaded liposome-in-chitosan-microspheres, respectively. Then blood samples were obtained from fossa orbitalis at different time points. The concentration of ferulic acid in blood was analyzed by a HPLC method using coumarin as internal standard. The data were analyzed by DAS program. The t(max), MRT and t(1/2beta) of liposome-in-chitosan-microspheres were 2.500, 7.487 and 7.818 h, respectively, which were much longer than crude drug and chitosan microspheres. This results demonstrated that liposome-in-chitosan-microspheres had better sus-tained-releasing property. The AUC of liposome-in-chitosan-microspheres was 6.08 times higher than crude drug and 1.21 times higher than chitosan microspheres, which verified that liposome-in-chitosan-microspheres could enhance oral absorption.
