The Value of Elastic Modulus Index as a Novel Surrogate Marker for Cardiovascular Risk Stratification by Dimensional Speckle-Tracking Carotid Ultrasonography.
10.4250/jcu.2016.24.3.215
- Author:
Ji Hyun YOON
1
;
In Jeong CHO
;
Hyuk Jae CHANG
;
Ji Min SUNG
;
Jinyong LEE
;
Hojin RYOO
;
Chi Young SHIM
;
Geu Ru HONG
;
Namsik CHUNG
Author Information
1. Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. hjchang@yuhs.ac
- Publication Type:Original Article
- Keywords:
Elastic modulus;
Carotid artery;
Cardiovascular disease
- MeSH:
Biomarkers*;
Cardiovascular Diseases;
Carotid Arteries;
Carotid Intima-Media Thickness;
Elastic Modulus*;
Humans;
Logistic Models;
Mechanics;
Ultrasonography*
- From:Journal of Cardiovascular Ultrasound
2016;24(3):215-222
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Carotid intima media thickness (CIMT) and the presence of carotid plaque have been used for risk stratification of cardiovascular disease (CVD). To date, however, the association between multi-directional functional properties of carotid artery and CVD has not been fully elucidated. We sought to explore the multi-directional mechanics of the carotid artery in relation to cardiovascular risk. METHODS: Four hundred one patients who underwent carotid ultrasound were enrolled between January 2010 and April 2013. A high risk of CVD was defined as more than 20% of 10-year risk based on the Framingham risk score. Using a speckle-tracking technique, the longitudinal and radial movements were analyzed in the B-mode images. Peak longitudinal and radial displacements, strain and strain rate were also measured. Beta stiffness and elastic modulus index were calculated from the radial measurements. RESULTS: Of the overall sample, 13% (52) of patients comprised the high-risk group. In multivariate logistic regression, CIMT and elastic modulus index were independently associated with a high-risk of CVD {odds ratio (OR): 1.810 [95% confidence interval (CI) 1.249–2.622] and OR: 1.767 (95% CI: 1.177–2.652); p = 0.002, 0.006, respectively}. The combination of CIMT and elastic modulus index correlated with a high-risk of CVD more so than CIMT alone. CONCLUSION: The elastic modulus index of the carotid artery might serve as a novel surrogate marker of high-risk CVD. Measurement of the multi-directional mechanics of the carotid artery using the speckle tracking technique has potential for providing further information over conventional B-mode ultrasound for stratification of CVD risk.
