Effects on micro-vessel density after pre-operative intra-arterial infusion chemotherapy in colorectal cancer.
- Author:
Qing LIN
1
;
Zhixia LI
;
Lijun ZHANG
;
Shurong ZHANG
;
Gongxue XU
;
Lianrui GUO
;
Dali AN
Author Information
- Publication Type:Clinical Trial
- MeSH: Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; drug therapy; Female; Humans; Infusions, Intra-Arterial; Male; Microcirculation; Middle Aged; Preoperative Care
- From: Chinese Journal of Oncology 2002;24(1):84-86
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effects of pre-operative intra-arterial infusion chemotherapy on colorectal cancer.
METHODSTwenty-eight patients with colorectal cancer, treated by surgery from February to October 2000, were divided into two groups randomly. There were 12 patients in group A (pre-operative intra-arterial infusion chemotherapy) and 16 in group B (control). Arterial contrast technique was used in group A, then mitromycin 10 mg, 5-Fu 1,000 mg, epirubicin 60 mg were given through Weidner's way.
RESULTSMicro-vessel density in the center, surface of the tumor and adjacent tissue around the tumor were 40.46 +/- 7.06, 52.27 +/- 18.40, 49.92 +/- 8.15 in group A, and 46.09 +/- 12.21, 73.44 +/- 22.06, 51.94 +/- 12.64 in group B. Micro-vessel density on the surface in group A was significantly lower than that of group B (P < 0.05), with no significance between the center and the adjacent tissue.
CONCLUSIONPre-operative intra-arterial infusion chemotherapy is able to reduce micro-vessel density on the surface of colorectal tumor.
