Association between platelet-activating factor acetylhydrolase gene polymorphism and intracranial hemorrhage in preterm infants.
- Author:
Qian ZHANG
1
;
Xin-Ru CHENG
;
Shu-Ling XU
;
Zan-Yang SHI
;
Guang-Yao SHENG
Author Information
- Publication Type:Journal Article
- MeSH: 1-Alkyl-2-acetylglycerophosphocholine Esterase; genetics; Female; Humans; Infant, Newborn; Infant, Premature; Intracranial Hemorrhages; etiology; genetics; Male; Polymorphism, Single Nucleotide
- From: Chinese Journal of Contemporary Pediatrics 2012;14(8):612-615
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore whether Val279Phe single nucleotide polymorphisms (SNPs) in the 9th exon of platelet-activating factor acetylhydrolase (PAF-AH) are associated with intracranial hemorrhage in preterm infants.
METHODSA case-control study was performed. Polymerase chain reaction (PCR) was used to test genotype and allele frequencies of the 9th exon Val279Phe SNPs of PAF-AH in 58 preterm infants with intracranial hemorrhage (hemorrhage group) and 65 preterm infants without intracranial hemorrhage (control group).
RESULTSThere were significant differences in genotype frequency of Val279Phe SNPs in the 9th exon of PAF-AH between the hemorrhage and control groups (P<0.05). Frequency of normal genotype in the hemorrhage group (63.8%) was significantly lower than in the control group (81.5%). In contrast, frequency of heterozygous genotype (34.5%) in the hemorrhage group was significantly higher than in control group (16.9%). There were also significant differences in allele frequency of Val279Phe SNPs in the 9th exon of PAF-AH between the two groups (P<0.05). T allele frequency in the hemorrhage group (19.0%) was significantly higher than in the control group (10.0%).
CONCLUSIONSVal279Phe SNPs in the 9th exon of PAF-AH may be associated with intracranial hemorrhage in preterm infants.
