Association of cytotoxic T lymphocyte-associated antigen-4+49A/G polymorphism with childhood type 1 diabetes mellitus: a meta-analysis.
- Author:
Shu-Ying LUO
1
;
Li-Na TAN
;
Hai-Yan WEI
;
Yao-Dong ZHANG
;
Yong-Xing CHEN
Author Information
- Publication Type:Journal Article
- MeSH: CTLA-4 Antigen; genetics; Diabetes Mellitus, Type 1; genetics; Genotype; Humans; Polymorphism, Genetic
- From: Chinese Journal of Contemporary Pediatrics 2012;14(9):683-688
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the association of cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) + 49A/G polymorphism with type 1 diabetes mellitus (T1DM) in children.
METHODSPapers about the association of CTLA4+49A/G polymorphism with T1DM in children were collected by searching PubMed, EBSCO, CBM, CNKI, and Wanfang Data. A meta-analysis was performed to examine differences in the genotypes (AG, GG, and GG+AG) and G allele at position 49 of the CTLA-4 gene between a childhood T1DM group and a control group.
RESULTSA total of 10 papers involving 1084 T1DM children and 1338 healthy children were included. The Meta-analysis was performed to evaluate the association of the genotypes (AG, GG, and GG+AG) and the G allele at position 49 of the CTLA-4 gene with T1DM using a fixed effect model according to the heterogeneity test results of all studies. The pooled OR values (95% CI) were 1.13 (0.97-1.33), 1.42 (1.16-1.75), 1.20 (1.03-1.40), and 1.21 (1.09-1.33), suggesting a significant difference in genotypes (AG, GG, and GG+AG) and the G allele at position 49 of the CTLA-4 gene between the two groups.
CONCLUSIONSCTLA-4 +49A/G polymorphism is associated with T1DM in children.
