Role of serum 25-hydroxyvitamin D in the diagnosis of vitamin D deficiency rickets.
- Author:
Xiao-Yan WANG
1
;
Chun-Hua JIN
;
Jian-Xin WU
;
Zhuo LIU
;
Mei LI
;
Na LI
Author Information
- Publication Type:Journal Article
- MeSH: Female; Humans; Infant; Male; ROC Curve; Rickets; blood; diagnosis; Vitamin D; analogs & derivatives; blood
- From: Chinese Journal of Contemporary Pediatrics 2012;14(10):767-770
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the role of serum 25-hydroxyvitamin D in the early diagnosis of vitamin D deficiency rickets.
METHODSConcentrations of serum 25(OH)D, calcium, phosphorus and alkaline phosphatase were measured in normal control (n=73), suspected rickets (n=45) and confirmed rickets groups (n=65). Receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of serum 25(OH)D for rickets.
RESULTSSerum 25(OH)D levels in the suspected and confirmed rickets groups were 83±30 and 72±31 nmol/L respectively, which was lower than in the normal control group (112±37 nmol/L) (P<0.01). There was no significant difference between the suspected and confirmed rickets groups (P>0.05). Vitamin D deficiency rates in the suspected and confirmed rickets groups were higher than in the control group (P<0.01). The ROC curve area of serum 25(OH)D for the diagnosis of rickets was 0.760 (95%CI 0.692-0.820, P<0.01), and the optimal operating point was 90.70 nmol/L (sensitivity 68.49%, specificity 72.73%). There was no significant difference in levels of calcium, phosphorus and alkaline phosphatase between the three groups (P>0.05).
CONCLUSIONSSerum 25(OH)D levels in infants with suspected and confirmed rickets are significantly reduced and this may reflect vitamin D deficiency . Therefore, it may be useful to check serum 25(OH)D levels in screening for rickets.