Association of prognosis with insulin-like growth factor receptor type I expression in gastric cancer patients: a meta-analysis.
- Author:
Yunhe GAO
1
;
Jianxin CUI
;
Hongqing XI
;
Weisong SHEN
;
Kecheng ZHANG
;
Jiyang LI
;
Wenquan LIANG
;
Chong HU
;
Bo WEI
;
Lin CHEN
Author Information
- Publication Type:Journal Article
- From: Chinese Journal of Gastrointestinal Surgery 2015;18(10):1051-1055
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo systemically evaluate the relationship between the expression of insulin-like growth factor receptor type I (IGF-1R) and prognosis in gastric cancer (GC) patients.
METHODSA literature search was conducted from PubMed, EMBASE, Web of Science, CNKI, Wanfang and VIP databases to retrieve the clinical studies relevant to IGF-1R expression and its prognostic value in GC patients. Meta-analysis was performed using STATA 12.0 software. The methodology was assessed according to the European Lung Cancer Working Party Quality Scale for Biological Prognostic Factors for Lung Cancer. The quality of studies was assessed using the Newcastle-Ottawa scale.
RESULTSFour eligible studies including 685 patients were enrolled for this meta-analysis. Analysis results suggested that up-regulation of IGF-1R in GC patients was significantly associated with TNM staging (OR=5.20, 95%CI:1.12 to 24.15, P=0.035), lymph node metastasis(OR=8.24, 95%CI:2.68 to 25.34, P=0.000) and distant metastasis(OR=17.34, 95%CI:6.52 to 46.15, P=0.000). Moreover, up-regulated IGF-1R expression was significantly associated with poor overall survival of gastric cancer patients(HR=2.63, 95% CI:1.29 to 5.40, Z=2.64, P=0.008).
CONCLUSIONHigh IGF-1R expression may be an adverse prognostic factor in gastric cancer patients.
