Clinical study on the relapsd leukemia patients with graft versus host disease after allogeneic hematopoietic stem cell transplantation.
- Author:
Xiao-Hui ZHANG
1
;
Hai-Xia FU
;
Kai-Yan LIU
;
Lan-Ping XU
;
Dai-Hong LIU
;
Huan CHEN
;
Wei HAN
;
Yu-Hong CHEN
;
Feng-Rong WANG
;
Jing-Zhi WANG
;
Ting ZHAO
;
Yu WANG
;
Yao CHEN
;
Xiao-Jun HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Graft vs Host Disease; Graft vs Leukemia Effect; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, Myeloid, Acute; Precursor Cell Lymphoblastic Leukemia-Lymphoma
- From: Chinese Journal of Hematology 2010;31(5):323-327
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the dissociation of graft-versus-leukemia (GVL) effects from graft-versus-host disease (GVHD) in the patients who experienced GVHD during leukemia relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
METHODSThe primary disease, disease status, GVHD, response to donor lymphocyte infusion (DLI) and prognosis were analysed in 11 leukemia patients who relapsed with GVHD after allo-HSCT.
RESULTSOf the 11 relapsed, 5 were acute lymphoblastic leukemia and 6 acute myeloid leukemia. Five received DLI before relapse and all developed post-DLI GVHD, including 2 grade II acute GVHD (aGVHD), 1 limited chronic GVHD (cGVHD) plus grade II aGVHD, and 2 extensive cGVHD. After relapse of the 5 patients, 2 received Chemo-DLI, one achieved CR with extensive cGVHD and then relapsed again, the other didn't achieved CR. The other 6 patients didn't received DLI before relapse and also developed post-HSCT GVHD while relapsing, including 3 extensive cGVHD, 1 grade I aGVHD and 2 grade II-IV aGVHD. After relapse, these 6 patients received Chemo-DLI, 2 achieved CR and then relapsed again, 4 didn't achieved CR.
CONCLUSIONThe elicited GVHD after allo-HSCT may not accompany effective GVL effects inhibiting leukemic relapse.