Prognostic significance of EBMT score for chronic myeloid leukemia patients in allogeneic stem cell transplantation.
- Author:
Jiong HU
1
;
Wei-ping ZHANG
;
Dan YANG
;
Wei TANG
;
Xian-min SONG
;
Ling WANG
;
Wei-li ZHAO
;
Wen WU
;
Jian-min WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Child; Female; Follow-Up Studies; Hematopoietic Stem Cell Transplantation; methods; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; diagnosis; surgery; Male; Middle Aged; Prognosis; Retrospective Studies; Risk Factors; Tissue Donors; Transplantation, Homologous; Young Adult
- From: Chinese Journal of Hematology 2011;32(2):75-78
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the risk factors of allogeneic stem cell transplantation (allo-SCT) for chronic myeloid leukemia (CML) in an attempt to avoid transplant risks.
METHODSA total of 121 CML patients received allo-SCT were analyzed retrospectively. The risk analysis was based on the EBMT score (gratwohl score) which included donor type, age of patients, disease status before transplantation, donor/recipient sex match and time interval between diagnosis to allo-SCT. Patients were divided into 3 risk groups based on their EBMT score: low risk (score 0-2), intermediate risk (3-4) and high-risk (5).
RESULTSThe median follow-up duration was 37 (1 - 126) months. The estimated 5-year overall survival (5 y-OS), non-relapse mortality (5 y-NRM) and relapse rate (5 y-RR) were (56.8 ± 5.0)%, (35.6 ± 4.9)% and (12.9 ± 3.7)%, respectively. The 5y-OS, NRM and RR were (66.0 ± 6.1)%, (28.8 ± 6.0)% and (7.8 ± 3.3)% in the low risk group being significantly superior to both intermediate-risk \[(47.2 ± 8.7)%, (43.6 ± 8.5)% and (18.7 ± 8.1)%\] and high-risk group \[(16.8 ± 15.2)%, (66.7 ± 25.5)% and (50.0 ± 25.0)%\] (P = 0.0015, 0.045 and 0.0053 for OS, NRM and RR respectively).
CONCLUSIONThe EBMT risk score can effectively predict the overall outcome, relapse and transplant-related mortality of allo-SCT for CML patients.
