Analysis the advantage of autologous mobilized peripheral blood mononuclear cells transplantation on lower limbs ischemia disease.
- Author:
Li-hua WU
1
;
Yan ZHANG
;
Ping-ping HUANG
;
Shang-zhu LI
;
Ying-xin ZHAO
;
Feng-lei LONG
;
Ren-min FU
;
Ya-li ZHENG
;
Chun-hua LIU
;
Qing-guo LIU
;
Jun-fan LI
;
Yi-min HU
;
Ning XU
Author Information
- Publication Type:Journal Article
- MeSH: Female; Humans; Ischemia; surgery; Lower Extremity; blood supply; Male; Middle Aged; Monocytes; transplantation; Peripheral Blood Stem Cell Transplantation; methods; Peripheral Vascular Diseases; surgery; Transplantation, Autologous
- From: Chinese Journal of Hematology 2011;32(2):112-114
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the efficacy and its correlation with species of transplant cells of autologous mobilized peripheral blood (PB) mononucleated cells (MNCs) transplantation on 59 patients with lower limbs ischemia.
METHODSFifty-nine patients were evaluated with symptoms scores and after that their PBMNCs were mobilized and collected and then injected into the ischemic area at equal distance. They effectiveness and scores were evaluated at 7th day and 4th month after therapy. The correlation of CD34(+) cells and of MNCs with effectiveness was analysed respectively, and formula for correlations between them and effectiveness was calculated.
RESULTSAfter MNCs injection, the effectiveness was observed both at 7th day and 4th month. The correlation of MNCs with effectiveness was stronger than that of CD34(+) cells (the effectiveness was represented by nimodipine value), According to the formula of nimodipine value, the value of the latter = 0.484 + 1.055 × CD34(+) cells number and the former = 0.288 + 0.401 × MNCs number with a correlation coefficient of R = 0.461 (P = 0.047) and R = 0.473 (P = 0.000) respectively.
CONCLUSIONAutologous mobilized PBMNCs number is a better indicator for effectiveness than CD34(+) cells number.
