Synthesis and antibacterial activity of 3-(5-substituted phenyl-1,3,4 oxadiazole-2-yl-methylenethio)-5-pyridin-3-yl-1,2,4 triazole-4-yl-amines.
- Author:
Guo-qiang HU
1
;
Song-qiang XIE
;
Qiu-ju XU
;
Wen-long HUANG
;
Hui-bin ZHANG
;
Sheng-tang HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Anti-Bacterial Agents; chemical synthesis; chemistry; pharmacology; Escherichia coli; drug effects; Oxadiazoles; chemical synthesis; chemistry; pharmacology; Proteus vulgaris; drug effects; Staphylococcus aureus; drug effects; Triazoles; chemical synthesis; chemistry; pharmacology
- From: Acta Pharmaceutica Sinica 2005;40(4):337-339
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study on synthesis and antibacterial activity evaluation of polyheterocycles.
METHODSThe condensation of 4-amino-3-pyridin-3-yl-4H-[1,2,4] triazole-5-thiol with 2-chloromethyl-5-substituted phenyl-[1,3,4] oxadiazoles gave the corresponding title heterocycle amines, and the in vitro antibacterial activity was primarily evaluated by the method of cup-plate diffusion solution.
RESULTSTwelve novel compounds were synthesized, and their structures were confirmed by IR, 1H NMR, MS and element analysis. Biological screening results demonstrated that most of the compounds prepared showed good antibacterial activity.
CONCLUSIONOxadiazoles incorporting pyridyl triazole ring may be a pharmacophor structure in the molecule for developing antibacterial candidate drugs.
