Chemistry of polysaccharide Lzps-1 from Ganoderma lucidum spore and anti-tumor activity of its total polysaccharides.
- Author:
Yan JIANG
1
;
Hao WANG
;
Long LÜ
;
Geng-yuan TIAN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antineoplastic Agents; chemistry; isolation & purification; pharmacology; Carcinoma, Lewis Lung; pathology; Killer Cells, Natural; drug effects; Mice; Molecular Weight; Polysaccharides; chemistry; isolation & purification; pharmacology; Reishi; chemistry; Sarcoma 180; pathology; Spores, Fungal; chemistry
- From: Acta Pharmaceutica Sinica 2005;40(4):347-350
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the structure and anti-tumor activity of polysaccharide from Ganoderma lucidum spore treated with microwave.
METHODSDEAE-cellulose and Sephadex G-50 column chromatography were used to isolate and purify the polysaccharide whose structure was characterized by using chemical and spectral methods.
RESULTS AND CONCLUSIONOne polysaccharide, named Lzps-1 was obtained from the water extract, with its molecular weight estimated by HPGPC to be 8000. Its structure was investigated to be glucan. The total polysaccharides, Lzps processed antitumor activity against sarcoma 180 and Lewis lung cancer in mice and enhanced the NK cell activity. Lzps-1 is obtained for the first time from Ganoderma spore Lzps has anti-tumor activity.
