Preparation of 8-chloro-adenosine long circulation liposomes and its pharmacokinetics in rats.
- Author:
Li YANG
1
;
Xian-rong QI
;
Jing SHI
;
Wen-qian CHEN
;
Qiang ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: 2-Chloroadenosine; administration & dosage; analogs & derivatives; pharmacokinetics; Animals; Antineoplastic Agents; administration & dosage; pharmacokinetics; Area Under Curve; Delayed-Action Preparations; Liposomes; Male; Nanostructures; Particle Size; Rats; Rats, Wistar
- From: Acta Pharmaceutica Sinica 2005;40(4):382-384
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo prepare 8-chloro-adenosine (8-Cl-A) long circulation liposomes with high entrapped efficiency and prolonged action-time of 8-Cl-A in vivo.
METHODSTo prepare 8-Cl-A long circulation liposomes of nanometer size by improved multiple emulsion. The entrapped efficiency, size and size distribution of 8-Cl-A long circulation liposomes were determined, and its pharmacokinetics in rats was evaluated.
RESULTSThe entrapped efficiency of 8-Cl-A long circulation liposomes was 62.70% and mean diameter of the liposomes was 79.9 nm. The pharmacokinetics studies indicated that 8-Cl-A long circulation liposomes showed higher drug concentration and larger AUC values than that of 8-Cl-A after iv to rats.
CONCLUSION8-Cl-A long circulation liposomes could prolong the action-time of 8-Cl-A in vivo.
