Establishment of a novel arrhythmia model in rats.
- Author:
Zhen-Wei PAN
1
;
Zhi-Yong WANG
;
Zhi-Min DU
;
Jun-Dong JIAO
;
De-Li DONG
;
Bao-Feng YANG
Author Information
- Publication Type:Journal Article
- MeSH: Amiodarone; pharmacology; Animals; Anti-Arrhythmia Agents; pharmacology; Arrhythmias, Cardiac; etiology; physiopathology; Coronary Disease; complications; Disease Models, Animal; Hyperlipidemias; complications; Male; Rats; Rats, Wistar
- From: Acta Pharmaceutica Sinica 2005;40(7):659-662
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo establish a novel arrhythmia model in rats.
METHODSCoronary artery occlusion was produced in hyperlipidemic rats after the animals were fed a high fat and cholesterol chow for 15 days. The incidence, duration and score of arrhythmias were determined 1 hour after coronary occlusion.
RESULTSThe incidence, duration and score of arrhythmia induced by coronary artery occlusion increased significantly in hyperlipidemic rats compared with those in normal rats (P < 0.05). In normal rats, pretreatment with amiodarone 60 mg x kg(-1) or verapamil 25 mg x kg(-1) 3 days before coronary artery occlusion did not influence the incidence, duration and score of arrhythmia (P > 0.05). In hyperlipidemic rats, amiodarone 60 mg x kg(-1) decreased the incidence, duration and score of arrhythmia (P < 0.05), but not verapamil 25 mg x kg(-1) (P > 0.05).
CONCLUSIONThe novel arrhythmia model induced by coronary artery occlusion in hyperlipidemic rats is reliable and similar to the pathophysiological state in human being.
