The biotransformation of kaempferitrin by human intestinal flora.
- Author:
Xiu-wei YANG
1
;
Jian-ye ZHANG
;
Wei XU
;
Jun LI
;
Wei-qing ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Bacteria; metabolism; Biotransformation; Fruit; chemistry; Humans; Intestines; microbiology; Kaempferols; isolation & purification; metabolism; pharmacokinetics; Mannosides; metabolism; Momordica; chemistry; Parabens; metabolism; Plants, Medicinal; chemistry; Proanthocyanidins; metabolism
- From: Acta Pharmaceutica Sinica 2005;40(8):717-721
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the biotransformation of kaempferitrin, a major chemical principle of the fruits of Siraitia grosvenori (Swingle) C. Jeffery, with human intestinal flora.
METHODSThe kaempferitrin was incubated with human intestinal flora. The biotransformation products were isolated and purified by chromatographic methods and the structures were determined by spectroscopic techniques.
RESULTSKaempferitrin was converted into kaempferol 3-O-alpha-L-rhamnoside (afzelin, I) , kaempferol 7-O-alpha-L-rhamnoside (II), kaempferol (III) and p-hydroxybenzoic acid (IV) by human intestinal flora. rhamnoside (II), kaempferol (III) and p-hydroxybenzoic acid (IV) by human intestinal flora.
CONCLUSIONThe structure of kaempferitrin can be biotransformatedly converted by human intestinal flora.
