Synthesis of 2-amino-4, 5-diarylpyrimidines and their protective effects against oxygen-glucose deprivation in PC12 cells.
- Author:
Mi-xiang GAO
1
;
Qing HE
;
Wen-yong HAN
;
Zun-ting ZHANG
Author Information
1. Key Laboratory of Ministry of Education for Medicinal Resource and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drug in Northwest of China, School of Chemistry and Materials Science, Shaanxi Normal University, Xi'an 710062, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Cell Hypoxia;
drug effects;
Cell Survival;
drug effects;
Glucose;
deficiency;
Molecular Structure;
Neuroprotective Agents;
chemical synthesis;
chemistry;
pharmacology;
PC12 Cells;
Pyrimidines;
chemical synthesis;
pharmacology;
Rats
- From:
Acta Pharmaceutica Sinica
2010;45(9):1123-1127
- CountryChina
- Language:Chinese
-
Abstract:
A series of 6 novel 2-amino-4, 5-diarylpyrimidines were synthesized by the reaction of isoflavones with guanidine. They were identified by the spectra of IR, 1H NMR, 13C NMR and elemental analysis. The protective effects of 2-amino-4, 5-diarylpyrimidines against oxygen-glucose deprivation leading by sodium hydrosulfite in PC12 cells were studied by MTT method. It was shown that 2-amino-4, 5-diarylpyrimidines exhibited neuroprotective effects against oxygen-glucose deprivation injury in PC12 cells, which could increase the amount of survival PC12 cells and reduce their injured degree in the model.
