Expression of Bcl-2 in the epithelial lining and clinical findings of keratocystic odotogenic tumor.
10.5125/jkaoms.2011.37.3.161
- Author:
In Hyuk LEE
1
;
So Young CHOI
;
Ji Hoon PARK
;
Chin Soo KIM
Author Information
1. Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyungpook National University, Daegu, Korea. kimcs@knu.ac.kr
- Publication Type:Original Article
- Keywords:
Bcl-2;
Keratocystic Odontogenic Tumor;
Dentigerous cyst
- MeSH:
Apoptosis;
Dentigerous Cyst;
Epithelial Cells;
Epithelium;
Formaldehyde;
Odontogenic Cysts;
Recurrence
- From:Journal of the Korean Association of Oral and Maxillofacial Surgeons
2011;37(3):161-168
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The odontogenic keratocysts demonstrated a high recurrence rate and a biologically aggressive nature. This might be due to unknown factors inherent in the epithelium or enzymatic activity in the fibrous wall. Bcl-2 protein is characterized by its ability to inhibit apoptosis. The aim of this study was to evaluate the expression and distribution of bcl-2 in the OKCs, its possible relationship with the tumorous characteristics, such as the aggressive nature and high recurrence rate, and its usefulness to differentiate OKCs from dentigerous cysts. MATERIALS AND METHODS: Formalin fixed paraffin-embedded tissue sections of 53 OKCs, and 44 dentigerous cyst were immunohistochemically analyzed quantitatively for the immunoreactivity of the bcl-2 protein with i-solution. RESULTS: More Bcl-2 expression was observed in the OKCs (mean34.387%) than dentigerous cyst (mean11.144%) with statistical significance (P<0.001). Seventeen and 15 of the 32 OKCs in this study showed positivity in the basal layer and basal/suprabasal layers, respectively. In dentigerous cyst, 2 of 3 showed positivity in the basal cell layer. CONCLUSION: Considering that bcl-2 over expression may lead to the increased survival of epithelial cells, this study demonstrated a possible relationship between the aggressive nature of OKC and the intrinsic growth potential of its lining epithelium. Furthermore, the basal/suprabasal distribution of bcl-2 positive cells was observed in some OKCs, which might have a significant impact on the behavior of cysts. The bcl-2 expression of OKCs can be useful for differentiating OKCs from dentigerous cysts.
