Preparation and characterization of oxaliplatin-loaded nanostructured lipid carriers.
- Author:
Hui ZHOU
1
;
Li-peng QIU
;
Xiao-xiao YAN
;
Lin LI
;
Xiang LI
;
Lu WANG
;
Mei LIU
;
Dong-kai WANG
Author Information
1. First Affiliated Hospital of China Medical University, Shenyang 110016, China. grace04john@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents;
administration & dosage;
chemistry;
Calorimetry, Differential Scanning;
Chromatography, High Pressure Liquid;
Delayed-Action Preparations;
Drug Carriers;
chemistry;
Drug Compounding;
Lipids;
chemistry;
Microscopy, Electron, Transmission;
Nanoparticles;
Organoplatinum Compounds;
administration & dosage;
chemistry;
Particle Size
- From:
Acta Pharmaceutica Sinica
2010;45(9):1177-1182
- CountryChina
- Language:Chinese
-
Abstract:
Oxaliplatin-loaded nanostuctured lipid carriers (OP-NLC) were prepared by ultrasonic emulsification method. And its optimal prescription was selected by orthogonal design. The laser light scattering technique, zeta potential analyzer, TEM, DSC, XRD and HPLC were employed to study the physicochemical parameters of OP-NLC, which displayed in terms of particle size, zeta potential, crystalline, drug loading and encapsulation efficiency. The results showed that OP-NLC had an average diameter of (111 +/- 20) nm, zeta potential of (-27.4 +/- 13.1) mV, encapsulation efficiency of (77.4 +/- 2.5) % and drug content of (0.8 +/- 1.5) mg mL(-1). TEM, DSC and XRD indicated that OP-NLC was spherical and the drug was dispersed as nanoparticles by means of non-crystalline. The in vitro release test showed that the drug could be sustained-released from NLC in buffer solution (pH 4.5) after a burst release in initial phase.
