G3BP: a promising target for cancer therapy.
- Author:
Hao ZHANG
1
;
Rong-guang SHAO
Author Information
1. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Carrier Proteins;
genetics;
metabolism;
DNA Helicases;
Drug Delivery Systems;
GTPase-Activating Proteins;
therapeutic use;
Humans;
Molecular Sequence Data;
Neoplasms;
drug therapy;
metabolism;
pathology;
Peptide Fragments;
therapeutic use;
Phosphorylation;
Poly-ADP-Ribose Binding Proteins;
RNA Helicases;
RNA Recognition Motif Proteins;
Signal Transduction;
ras GTPase-Activating Proteins;
metabolism;
src Homology Domains;
genetics
- From:
Acta Pharmaceutica Sinica
2010;45(8):945-951
- CountryChina
- Language:Chinese
-
Abstract:
G3BP (Ras-GTPase-activating protein SH3 domain binding protein), a protein which binds to RasGAP SH3 domain, belongs to RNA-binding protein family, implicating in the downstream of Ras signaling. G3BP harbors the activities of endoribonuclease and DNA helicase, and can induce stress granules formation. G3BP plays a general role in the signal pathways of cell proliferation, differentiation, apoptosis and RNA metabolism. It has been shown to be over-expressed in a number of human malignancies and has a close relationship with tumor invasion and metastasis. Given that it has been implicated in several pathways that are known to be involved in cancer biology, G3BP may provide a new target for cancer therapy.
