Synthesis and investigation and antifungal and antibacterial properties of some 2-amino thiazole derivatives
- Author:
Dao Thanh Tran
- Publication Type:Journal Article
- Keywords:
thiazole
- MeSH:
2-aminothiazole;
Analogs & derivatives
- From:Pharmaceutical Journal
1999;282(10):13-15
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Condensing 2-amino-4-methyl-5-carbe thoxythiazole obtained from the cyclization process between thioure and ethylacetoacetate and oidine with some acylating agents to yield 9 new compounds of thiazole. All of them were screened for their invitro antibacterial and antifungal activities with respect to clotrimazol and cloramphenicol. The results showed that [2-(3,5-substuted salicylamido)-4-methyl-5-car-bethoxythiazole] compounds are active against gram-positive bacteria.
