Recent advances in the study of new antifungal lead compounds.
- Author:
Sheng-zheng WANG
1
;
Chun-quan SHENG
;
Wan-nian ZHANG
Author Information
1. School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
- Publication Type:Journal Article
- MeSH:
Antifungal Agents;
chemical synthesis;
chemistry;
pharmacology;
therapeutic use;
Fungi;
drug effects;
Heterocyclic Compounds;
chemical synthesis;
chemistry;
pharmacology;
Humans;
Lipopeptides;
chemistry;
pharmacology;
therapeutic use;
Molecular Structure;
Mycoses;
drug therapy;
Nitriles;
chemistry;
pharmacology;
therapeutic use;
Plant Extracts;
chemical synthesis;
chemistry;
isolation & purification;
pharmacology;
Plants, Medicinal;
chemistry;
Pyridines;
chemistry;
pharmacology;
therapeutic use;
Quinazolines;
chemistry;
pharmacology;
therapeutic use;
Quinones;
chemical synthesis;
chemistry;
pharmacology;
Structure-Activity Relationship;
Thiazoles;
chemistry;
pharmacology;
therapeutic use;
Triazoles;
chemistry;
pharmacology;
therapeutic use
- From:
Acta Pharmaceutica Sinica
2010;45(8):966-975
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, the incidence and mortality rate of invasive fungal infection have increased dramatically, and it is of great significance to develop novel antifungal agents with new chemical structure and new mode of action. In this review, novel antifungal lead compounds reported from 2007 to 2009 are reviewed. Moreover, their chemical structures, antifungal activities and structure-activity relationships have been summarized, which can provide useful information for future study of antifungal agents.
