Vitro antitumor activity and synthesis of the key intermediate of bakuchiol.
- Author:
Hong-li CHEN
1
;
Hui-jin FENG
;
Yuan-chao LI
Author Information
1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents, Hormonal;
pharmacology;
Antineoplastic Agents, Phytogenic;
chemical synthesis;
isolation & purification;
pharmacology;
Breast Neoplasms;
pathology;
Cell Line, Tumor;
Cell Proliferation;
drug effects;
Female;
Humans;
Inhibitory Concentration 50;
Phenols;
chemical synthesis;
isolation & purification;
pharmacology;
Plants, Medicinal;
chemistry;
Psoralea;
chemistry;
Tamoxifen;
pharmacology
- From:
Acta Pharmaceutica Sinica
2010;45(4):467-470
- CountryChina
- Language:Chinese
-
Abstract:
The in vitro antitumor activity of bakuchiol was exploited, compared with tamoxifen. The result of biological activities showed that bakuchiol could inhibit human breast cancer and the IC50 values were 2.89 x 10(-5) mol L(-1) and 8.29 x 10(-3) mol L(-1) against the cells line T-47D and MDA-MB-231 respectively. On the other hand, the key intermediate to synthesize bakuchiol was obtained by the method of Ireland-Claisen rearrangement. Comparing with traditional Claisen rearrangement, the reaction conditions are milder and the reaction reagents are safer.
