Monomeric indole alkaloids from the aerial parts of Catharanthus roseus.
- Author:
Xiang-Zhang ZHONG
1
;
Guo-Cai WANG
;
Ying WANG
;
Xiao-Qi ZHANG
;
Wen-Cai YE
Author Information
1. Department of Phytochemistry, China Pharmaceutical University, Nanjing 210009, China.
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents, Phytogenic;
chemistry;
isolation & purification;
Catharanthus;
chemistry;
Ibogaine;
analogs & derivatives;
chemistry;
isolation & purification;
Indole Alkaloids;
chemistry;
isolation & purification;
Molecular Structure;
Plant Components, Aerial;
chemistry;
Plants, Medicinal;
chemistry;
Vinblastine;
analogs & derivatives;
chemistry;
isolation & purification
- From:
Acta Pharmaceutica Sinica
2010;45(4):471-474
- CountryChina
- Language:Chinese
-
Abstract:
Catharanthus roseus (L.) G. Don is a plant of the Catharanthus genus of Apocynaceae which has been reported to have therapeutic effects of detoxication and anticancer. In order to further study the alkaloid constituents of C. roseus, the aerial parts of the plant were extracted with 95% EtOH, and then treated with 2% H2SO4 and NH3H2O to obtain total alkaloids. The total alkaloids were separated and purified by column chromatography over silica gel and prepared by high performance liquid chromatography (HPLC). Their structures were elucidated on the basis of physicochemical properties and spectral data. A new alkaloid together with five known compounds were isolated and identified as vindolinine B (1), lochnericine (2), horhammericine (3), vindorosine (4), vindoline (5), and coronaridine (6). Compound 1 is a new compound and named as vindolinine B.
