Synthesis of thienopyridine derivatives and its anti-platelet activity in vivo.
- Author:
Yun-Song ZHOU
1
;
Ping-Bao WANG
;
Ying LIU
;
Ji-Fang CHEN
;
Nan YUE
;
Deng-Ke LIU
Author Information
1. Graduate School, Tianjin Medical University, Tianjin 300070, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Male;
Molecular Structure;
Platelet Aggregation;
drug effects;
Platelet Aggregation Inhibitors;
chemical synthesis;
chemistry;
pharmacology;
Purinergic P2Y Receptor Antagonists;
chemical synthesis;
chemistry;
pharmacology;
Random Allocation;
Rats;
Rats, Wistar;
Thienopyridines;
chemical synthesis;
chemistry;
pharmacology
- From:
Acta Pharmaceutica Sinica
2011;46(1):70-74
- CountryChina
- Language:Chinese
-
Abstract:
To explore novel ADP receptor inhibitors with anti-thrombotic activity, eighteen compounds were synthesized and their structures were confirmed by 1H NMR and MS. The results showed that the activity of compound C1 was superior to ticlopidine in platelet aggregation inhibition tests in vivo and worthy for further investigation. Compounds A4, B2, C4 and C7 possessed moderate platelet aggregation inhibitory activities.
