Design push-pull osmotic pump tablets of famotidine based on an expert system for the formulation design of osmotic pump of poor water-soluble drug.
- Author:
Zhi-Hong ZHANG
1
;
Jie JIN
;
Hong-Wu ZHANG
;
Wei XIN
;
Guo-Bin JIA
;
Wen-Fang WU
;
Wei-San PAN
Author Information
1. Shenyang Pharmaceutical University, Shenyang 110016, China.
- Publication Type:Journal Article
- MeSH:
Delayed-Action Preparations;
Drug Delivery Systems;
methods;
Excipients;
chemistry;
Expert Systems;
Famotidine;
administration & dosage;
chemistry;
Osmosis;
Solubility;
Tablets;
Water
- From:
Acta Pharmaceutica Sinica
2011;46(1):109-114
- CountryChina
- Language:Chinese
-
Abstract:
The purpose of this study is to design push-pull osmotic pump (PPOP) tablets of famotidine using the expert system for the formulation design of osmotic pump of poor water-soluble drug which had been established by the authors. Firstly, the parameters which were requisite of the system input were obtained from literatures and experimental tests. Then the parameters were input into the system, and the program was run. The system displayed the designed formulations sequential. Finally, famotidine PPOP was prepared according to the designed formulations and the in vitro dissolution was carried out. It was found out that the target formulation of famotidine PPOP which could release for 24 hours was obtained in a very short period. Meanwhile, the practicability of the established expert system was proved.
