Preparation of polyelectrolyte microcapsules containing ferrosoferric oxide nanoparticles.
- Author:
Xiao-Qing LIU
1
;
Chun-Li ZHENG
;
Jia-Bi ZHU
Author Information
1. Pharmaceutical Research Institute, China Pharmaceutical University, Nanjing 210009, China.
- Publication Type:Journal Article
- MeSH:
Calcium Carbonate;
chemistry;
Capsules;
Chemical Precipitation;
Drug Carriers;
Drug Compounding;
methods;
Drug Delivery Systems;
Electrolytes;
chemistry;
Ferrosoferric Oxide;
chemistry;
Magnetite Nanoparticles;
Microscopy, Electron, Scanning;
Microscopy, Fluorescence;
Particle Size;
Rhodamines;
administration & dosage;
chemistry;
Serum Albumin, Bovine;
administration & dosage;
chemistry
- From:
Acta Pharmaceutica Sinica
2011;46(1):115-120
- CountryChina
- Language:Chinese
-
Abstract:
In this study, polyelectrolyte microcapsules have been fabricated by biocompatible ferrosoferric oxide nanoparticles (Fe3O4 NPs) and poly allyamine hydrochloride (PAH) using layer by layer assembly technique. The Fe3O4 NPs were prepared by chemical co-precipitation, and characterized by transmission electron microscopy (TEM) and infrared spectrum (IR). Quartz cell also was used as a substrate for building multilayer films to evaluate the capability of forming planar film. The result showed that Fe3O4 NPs were selectively deposited on the surface of quartz cell. Microcapsules containing Fe3O4 NPs were fabricated by Fe3O4 NPs and PAH alternately self-assembly on calcium carbonate microparticles firstly, then 0.2 molL(-1) EDTA was used to remove the calcium carbonate. Scanning electron microscopy (SEM), Zetasizer and vibrating sample magnetometer (VSM) were used to characterize the microcapsule's morphology, size and magnetic properties. The result revealed that Fe3O4 NPs and PAH were successfully deposited on the surface of CaCO3 microparticles, the microcapsule manifested superparamagnetism, size and saturation magnetization were 4.9 +/- 1.2 microm and 8.94 emu x g(-1), respectively. As a model drug, Rhodamin B isothiocyanate labeled bovine serum albumin (RBITC-BSA) was encapsulated in microcapsule depended on pH sensitive of the microcapsule film. When pH 5.0, drug add in was 2 mg, the encapsulation efficiency was (86.08 +/- 3.36) % and the drug loading was 8.01 +/- 0.30 mg x m(L-1).
