Modulating drug loading and release profile of beta-cyclodextrin polymers by means of cross-linked degree.
- Author:
Qi-fang WANG
1
;
San-ming LI
;
Yu-yang ZHANG
;
Hong ZHANG
Author Information
1. College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
- Publication Type:Journal Article
- MeSH:
Carbon Isotopes;
Cross-Linking Reagents;
chemistry;
Delayed-Action Preparations;
Drug Carriers;
Drug Compounding;
Drug Delivery Systems;
Ibuprofen;
administration & dosage;
chemistry;
Magnetic Resonance Spectroscopy;
Pharmaceutical Preparations;
administration & dosage;
chemistry;
Polymers;
chemistry;
Solubility;
Spectroscopy, Fourier Transform Infrared;
beta-Cyclodextrins;
chemistry
- From:
Acta Pharmaceutica Sinica
2011;46(2):221-226
- CountryChina
- Language:English
-
Abstract:
The purpose of the present study is to use beta-cyclodextrin polymers (beta-CDP) with different cross-linked degree (CLD) to form inclusion complexes with ibuprofen and examine the effects of structural and compositional factors of beta-CDP on its drug loading and release behaviors. A series of beta-CDP with different CLD were synthesized and characterized by Fourier Transform Infrared Spectroscopy (FT-IR) and 13C NMR spectrum. The beta-CDP was systemically characterized for the relation between the CLD of beta-CDP and the drug loading and release as well. The results of FT-IR and 13C NMR showed that similar peak-shaped vibration of beta-CDP and beta-CD implies that the polymer keeps the original characteristic structure of beta-CD. The CLD of the beta-CDP played a critical role in the drug loading and release, increasing the CLD resulted in reduction of drug loading, but increase in drug release.
