Application of nuclear magnetic resonance to the determination of the configuration of glycoside bond.
- Author:
Yue-hu PEI
1
;
Hui-ming HUA
;
Zhan-lin LI
;
Gang CHEN
Author Information
1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
- Publication Type:Journal Article
- MeSH:
Carbohydrate Conformation;
Carbon Isotopes;
Glycosides;
chemistry;
Magnetic Resonance Spectroscopy;
methods;
Monosaccharides;
chemistry
- From:
Acta Pharmaceutica Sinica
2011;46(2):127-131
- CountryChina
- Language:Chinese
-
Abstract:
In the structural determination of natural glycosides, nuclear magnetic resonance (NMR) is an important approach in determining the configuration of glycoside bond. The test of coupling constant of the anomeric proton and chemical shift of the anomeric carbon are two common methods, but these methods are not suitable for some sugars. For those sugars, detailed 13C NMR analysis is an alternative choice. This paper summarizes the characteristics of 1H and 13C NMR data of the common monosaccharides published in the literatures, in order to search an approach to determine the configuration of glycoside bond.
