Progress on Wnt/beta-catenin signal pathway regulating the cartilage metabolism in osteonecrosis.
- Author:
Jian XIE
1
;
Pei-jian TONG
;
Lu-wei XIAO
Author Information
1. Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, Zhejiang, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Cartilage;
metabolism;
Humans;
Mice;
Osteonecrosis;
metabolism;
Signal Transduction;
physiology;
Wnt Signaling Pathway;
physiology;
beta Catenin;
physiology
- From:
China Journal of Orthopaedics and Traumatology
2013;26(7):613-616
- CountryChina
- Language:Chinese
-
Abstract:
More and more scholars agreed with the viewpoint that osteonecrosis relates with the metabolic activity of chondrocyte. Moreover,the activation of beta-catenin among Wnt/beta-catenin signal pathway can promote differentiation of chondrocyte and can promote differentiated cell death. So it suggests that this signal pathway should have an effect to occurrence and development of osteonecrosis by regulating the metabolic activity of chondrocyte. Through the establishment of conditional beta-catenin knockout mice,it is helpful to understand the pathogenesis of Wnt/beta-catenin signal pathway regulating cartilage metabolism. By the way we can understand the pathogenesis of osteonecrosis and give a targeted treatment to the disease. This article reviewed the relationship of three aspects of Wnt/beta-catenin signal pathway, cartilage metabolism and osteonecrosis.
