Relationship between rs3865418 polymorphism of neural precursor cell expressed developmentally downregulated 4-like gene and obesity in Kazakh general population.
- Author:
Hong-Mei WANG
1
;
Jing HONG
;
Wen-Li LUO
;
Jian-Hang CHANG
;
Xiao-Guang YAO
;
Nan-Fang LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Asian Continental Ancestry Group; genetics; Case-Control Studies; China; Cross-Sectional Studies; Endosomal Sorting Complexes Required for Transport; genetics; Ethnic Groups; genetics; Female; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Nedd4 Ubiquitin Protein Ligases; Obesity; genetics; Polymorphism, Genetic; Ubiquitin-Protein Ligases; genetics
- From: Acta Academiae Medicinae Sinicae 2011;33(5):533-537
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationships between rs3865418 polymorphism of neural precursor cell expressed developmentally downregulated 4-like gene and obesity in Kazakh general population.
METHODSBased on a cross-sectional epidemiological study in a Kazakh general population, a case-control study was conducted. The rs3865418 polymorphism in a Kazakh general population (856 subjects, including 364 males and 492 females; 478 in obesity group and 378 in normal control group) was genotyped by TaqMan polymerase chain reaction, and the relationship between rs3865418 polymorphism and obesity was analyzed.
RESULTSThe rs3865418 polymorphism was successfully genotyped in 851 Kazakh subjects. The distribution of the genotypes and alleles of rs3865418 polymorphism did not differ significantly between the obesity group and normal control group in terms of general populations, males, and females (all P > 0.05). The waist circumference showed a tendency of C/C > C/T > T/T in males and C/C < C/T < T/T in females, but without statistical significance (P > 0.05).
CONCLUSIONSThe rs3865418 polymorphism of neural precursor cell expressed developmentally downregulated 4-like gene may not be associated with obesity in Kazakh general population. In other words, it is not a predisposing factor for obesity in Kazakh.
