Correlation of CT presentation with histo-differentiation and p53 and Ki67 expressions in gastric cancer.
- Author:
Jing-Yu WANG
1
;
Dong DONG
;
Chun-Lai DAI
;
Shu-Qing WANG
;
Dan-Dan ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Female; Humans; Ki-67 Antigen; metabolism; Male; Middle Aged; Stomach Neoplasms; diagnostic imaging; metabolism; pathology; Tomography, Spiral Computed; Tumor Suppressor Protein p53; metabolism; Young Adult
- From: Acta Academiae Medicinae Sinicae 2011;33(5):555-559
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the relationship between spiral CT findings and histological differentiation and expressions of p53 and Ki67 in gastric carcinoma.
METHODSTriphasic spiral CT was performed in 158 patients. CT findings included maximal diameter and thickness of tumor in three dimensional CT images, degree of enhancement, mucous situation, lymph nodes, and visceral metastasis were recorded. The expressions of p53 and Ki67 were detected with immunohistochemistry and reverse transcription polymerase chain reaction.
RESULTSThe thickness of tumor (chi2 = 5.554, P = 0.018), degree of enhancement (chi2 = 4.978, P = 0.026), and lymph nodes metastasis (chi2 = 6.061, P = 0.014) in the three dimensional CT images were significantly correlated with tumor histological differentiation. Lymph nodes metastasis was significantly correlated with the expression of p53 (chi2 = 5.028, P = 0.025). The expression of Ki67 was significantly correlated with the thickness of tumor (chi2 = 5.674, P = 0.017) and lymph nodes metastasis (chi2 = 5.028, P = 0.025).
CONCLUSIONMulti-slice CT is a simple and noninvasive technique, and can be used for assessing the histological differentiation of gastric cancer as well as the expressions of p53 and Ki67 before the operation.
